same type. • Formally, this model is a stochastic process (Markov process). Birth event Mutation event Random Time 𝑢12 𝜆1A computational model for cancer initiation 4 A single cell • Consider process). Birth event Mutation event Random Time ~ Exp mutation rate growth rate #include std::mt19937_64 rnd_generator; std::exponential_distribution<> exp{rate}; double time = exp(rnd_generator); dynamics: 𝑢23 𝜆2 𝑢01 𝑢12 First Advantageous Mutation Clonal Expansion Neutral Mutation time to malignancy Input: Parameters. Output: Population at desired times: N𝑖 𝑡1 , N𝑖 𝑡2 , … • Need

Congratulations, you now have installed django CMS and created your first page. If you need to log in at any time, append ?toolbar_on to the URL and hit Return. This will enable the toolbar, from where you can log components, and choose them for each page as required. A page’s template can be switched for another at any time. We recommend creating a base.html template, shared by all the applications in the project, that your containing Python code that won’t be loaded until the server restarts. You have to restart the server each time you want to apply a modification made to this file or any views attached to thereof. Restarting the

Guide Copyright © 2009 Canonical Limited 2. Student Responsibilities • Students should arrive on time and stay until the session is dismissed. The instructor should be notified if you expect to arrive recommended that you teach each topic covered in the training material. However, if you are running short of time, optional topics are indicated in the Instructor Notes of each lesson. 4.2. Instructional Methods devel- opers to create a new Linux OS. Figure 1.3. Mark Shuttleworth Based on the principles of time-based releases, a strong Debian foundation, the GNOME desktop, and a com- mitment to freedom, this

How to add additional artifacts to the driver ODBC JDBC driver Deprecated legacy ODBC driver JDBC time zones JDBC tracing Apache Hive Cassandra ClickHouse Couchbase Database driver IBM Db2 Greenplum sudo rpm -Uvh dbeaver-.rpm This feature is available only in Windows and macOS. From time to time, DBeaver automatically checks for new versions. If the check is not disabled and a new version License owner's name and company name; License owner's email; Issue time is the date of the initial license purchase; The end time is the date the license expires; Number of users: single user or multiuser

How to add additional artifacts to the driver ODBC JDBC driver Deprecated legacy ODBC driver JDBC time zones JDBC tracing Apache Hive Cassandra ClickHouse Couchbase Database driver IBM Db2 Greenplum sudo rpm -Uvh dbeaver-.rpm This feature is available only in Windows and macOS. From time to time, DBeaver automatically checks for new versions. If the check is not disabled and a new version License owner's name and company name; License owner's email; Issue time is the date of the initial license purchase; The end time is the date the license expires; Number of users: single user or multiuser

How to add additional artifacts to the driver ODBC JDBC driver Deprecated legacy ODBC driver JDBC time zones JDBC tracing Apache Hive Cassandra ClickHouse Couchbase Cloud settings in DBeaver Driver sudo rpm -Uvh dbeaver-.rpm This feature is available only in Windows and macOS. From time to time, DBeaver automatically checks for new versions. If the check is not disabled and a new version License owner's name and company name; License owner's email; Issue time is the date of the initial license purchase; The end time is the date the license expires; Number of users: single user or multiuser

Reads are getting slower while writes are still fast 125 Nodes seem to freeze after some period of time 126 Nodes are dying with OOM errors 126 Nodetool or JMX Connections Failing on Remote Nodes 126 demo portfolio manager application that showcases how you can use Apache Cassandra to back a real-time web application developed in Java and using the Cassandra Query Language (CQL) JDBC driver. The demo the current stock price and historical market data (end-of-day price) for each stock going back in time. Running the Demo Web Application Before you begin, make sure you have installed, configured, and

an open source project which provides a set of components (Serving and Eventing) that introduce event-driven and serverless capabilities for Kubernetes clusters for deploying, running, and managing cluster should support 1000 sequential (interval 5s) Knative service provisionings with route ready time <= 30s. Type Info K8s Cluster Capacity 12 nodes in 3 zones, 16 vCPU * 64 Gi MEM Knative Version Knative Service provisioning • Random missing endpoint issue is fixed #IstioCon • Tuning debounce time could mitigate the envoy overload issue Istio scalability optimization during Knative Service provisioning

Goal ■ Understand Istio control-plane performance to support eBay scale ■ Proxy config convergence time (CDS, EDS, LDS, RDS push times) ■ Resource usage (CPU, memory, etc.) ○ Secondary Goal ■ Fine-tune Setup ○ Create Gateway Pods & thousands of Pods with sidecar Envoys ○ Measure Config convergence time ■ Time taken by all sidecars to get config from Pilot without any errors ■ For thousands of services cluster ○ Disabled egress traffic to restrict config pushed to sidecars ● Main Takeaways ○ P99.9 time from single Pilot instance to 0 - 3,000 sidecars < 1 second ○ Pilot CPU & memory within acceptable

continuous replication ● Compliance ● Easy Rollbacks for Application state ● Malware protection ● Time Travel for data sets ● Incremental analytics 37 © 2022 Cloudera, Inc. All rights reserved. OBJECT object - multiple versions ● A group of objects as a unit ○ Consistent with each other ○ Point in time, together as a group ● Examples : ○ Application updating multiple rows of a table to get to a consistent HA Raft Ring Immutable Data blocks Snapshotting the object NameSpace is enough to get point in time image of the object store 41 © 2022 Cloudera, Inc. All rights reserved. SNAPSHOT DESIGN : KEY IDEAS