evolution quantitatively. (e.g. predict the window of opportunity for screening) National Cancer Institute – What is Cancer 3A computational model for cancer initiation 4 A single cell • Consider a bunch Myeloid Leukemia 6 CML prevalence data points come from the SEER Incidence Data, National Cancer institute. SEER (Surveillance, Epidemiology, and End Results Program) • One genetic alteration (BCR-ABL)