problematic values in the WSGI environment usually are REMOTE_ADDR and HTTP_HOST. You can configure your httpd to pass these headers, or you can fix them in middleware. Werkzeug ships a fixer that will solve some $proxy_add_x_forwarded_for; proxy_set_header X-Forwarded-Proto $scheme; } } If your httpd is not providing these headers, the most common setup invokes the host being set from X-Forwarded-Host uwsgi_pass unix:/tmp/yourapplication.sock; } mod_wsgi (Apache) If you are using the Apache [https://httpd.apache.org/] webserver, consider using mod_wsgi [https://github.com/GrahamDumpleton/mod_wsgi]. Watch

problematic values in the WSGI environment usually are REMOTE_ADDR and HTTP_HOST. You can configure your httpd to pass these headers, or you can fix them in middleware. Werkzeug ships a fixer that will solve some X-Forwarded-For $proxy_add_x_forwarded_for; proxy_set_header X-Forwarded-Proto $scheme; } } If your httpd is not providing these headers, the most common setup invokes the host being set from X-Forwarded-Host 2.4. Most notably, the syntax for directory permissions has changed from httpd 2.2 Order allow,deny Allow from all to httpd 2.4 syntax Require all granted For more information consult the mod_wsgi